01
IAM
Immobilised artificial membrane
Phospholipid immobilised on the HPLC stationary phase reproduces the environment of a cell membrane. Retention is proportional to a compound's affinity for phospholipid.
STEVENAGE, UK SINCE 2015
Biomimetic HPLC Measurements and ADMET Predictions for Drug Discovery
From a very small amount of compound, we perform six chromatographic measurements and use the resulting experimental data in 22 validated models to predict key ADMET and in vivo distribution properties, including plasma protein binding, volume of distribution, blood–brain distribution and tissue binding. The approach helps drug-discovery teams select compounds with more favourable properties earlier, reducing the risk of costly late-stage failure. Measurements can be performed rapidly at a fraction of the cost of many animal studies, while reducing the need for animal experiments.
Assay Panel
IAM
Immobilised artificial membrane affinity
HSA
Human serum albumin binding
AGP
α1-acid glycoprotein binding
CHI logD
Lipophilicity, pH 2 / 7.4 / 10.5
0+
Pharmaceutical & Biotech Clients
0+
Compounds Profiled Globally
Global
Emerging Biotech to Pharma
0+
Years Biomimetic HPLC Expertise
ESTABLISHED PLATFORM
Trusted across pharmaceutical drug discovery
Bio-Mimetic Chromatography’s services have been used by more than 20 pharmaceutical and biotechnology companies, from global pharmaceutical organisations to specialist and emerging biotech companies.
Our biomimetic screening platform supports drug-discovery teams with experimentally measured data for compound profiling, permeability, distribution and safety-related applications. Client identities and project details remain confidential.
- Established experimental workflows
- Interpretation for progression decisions
- Reproducible calibrated measurements
- Transferable methods and training
THE METHOD
Six chromatographic measurements, one integrated biomimetic profile
Instead of predicting behaviour from structure, we measure affinity against the partners that represent important determinants of drug distribution: membrane phospholipid and the two major plasma proteins.
02
HSA
Human serum albumin
Human serum albumin bound to the column measures plasma protein binding directly, without ultrafiltration or dialysis artefacts.
03
AGP
α1-acid glycoprotein
The second major plasma protein. Combining AGP with HSA and IAM affinity gives the distribution picture that single-parameter logP screening cannot.
THE COMPANY
A platform built for continuity
Bio-Mimetic Chromatography Ltd brings together validated methods, calibrated assays, specialist laboratory workflows and an expanding body of experimental data. The capability is designed to support repeatable delivery, method transfer and future scientific leadership.
We measure, interpret and explain. Every dataset is delivered with the calibration behind it and a written interpretation of what it means for compound ranking and progression.
OUR AIM
Better candidates, fewer animal studies
Reduced animal testing
Reduced costs
Reduced late-stage attrition
Early dose estimation
THE METHOD
Measurement, modelling, training
Four connected strands of work, all built on the same measured properties.
WHO THIS IS FOR
Three kinds of laboratory, one measurement platform
Drug discovery teams
Rank compound series on distribution behaviour before committing to in vivo work.
- Compound ranking on measured, not calculated, data
- Free-drug concentration and drug efficiency
- Early human dose estimation
Cosmetic & consumer science
Use membrane and protein affinity to guide skin permeation and formulation choices.
- Ingredient permeation behaviour
- Formulation comparison on measured properties
- Claim support built on published methodology
Academia & analytical labs
Set the methods up in your own laboratory, with calibration standards and training.
- Method transfer and long-term technical support
- Valko calibration mixtures for comparable data
- Courses for MSc, PhD and industry scientists
CREDIBILITY
Published methodology, taught internationally
The methods behind our service are documented in peer-reviewed literature and reference texts, and taught to industry and university scientists.
- Author of Physicochemical and Biomimetic Properties in Drug Discovery
- Editor and contributor on HPLC physchem profiling texts
- Courses delivered to pharmaceutical and academic labs
- Valko calibration mixtures used for inter-lab comparison
QUESTIONS
Frequently asked
If your question is not here, write to us and we will answer it directly.
What does a measurement package cost?
The biomimetic and physicochemical panel starts from £420 per compound. Scope, turnaround and price are confirmed in writing before any work begins.
How much material do you need?
Only small quantities are required, as measurement is by HPLC with UV or MS detection. We confirm the exact requirement with you when scoping the work.
Why is biomimetic HPLC better than calculated properties?
Calculated logP tells you about a structure; measured affinity for phospholipid, albumin and AGP tells you how the actual molecule behaves against real biological partners. Retention time is directly proportional to that affinity.
Can our own laboratory run these methods?
Yes. We set the methods up on your instruments, supply calibration mixtures, and provide long-term technical support and training.
Do you provide interpretation, or just numbers?
Every dataset is delivered with the calibration behind it and a written interpretation of what the results mean for compound ranking and progression.
START A CONVERSATION
Discuss your screening programme
New biomimetic screening programmes are supported through our strategic collaboration with AsedaSciences. Other enquiries remain with Bio-Mimetic Chromatography.