Publications
​Latest Publications

Lipophilicity and biomimetic properties measured by HPLC to support drug discovery

Valkó, K. (2016). Lipophilicity and biomimetic properties measured by HPLC to support drug discovery. Journal of Pharmaceutical and Biomedical Analysis, 130, pp.35-54.

In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery

Valko, K., Teague, S. and Pidgeon, C. (2017). In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery. ADMET and DMPK, 5(1), p.14.

How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery

How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery

Teague, S. and Valko, K. (2017). How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery. European Journal of Pharmaceutical Sciences.
​​Recent review papers in the field:

Advances in Immobilized Artificial Membrane  (IAM) Chromatography for Novel Drug Discovery

Tsopelas, F., Vallianatou, T. and Tsantili-Kakoulidou, A. (2016). Advances in immobilized artificial membrane (IAM) chromatography for novel drug discovery. Expert Opinion on Drug Discovery, 11(5), pp.473-488.

Recent advances in lipophilicity measurement by reversed-phase high-performance liquid chromatography

Liang, C. and Lian, H. (2015). Recent advances in lipophilicity measurement by reversed-phase high-performance liquid chromatography. TrAC Trends in Analytical Chemistry, 68, pp.28-36.

Estimation of Biological Properties by Means of Chromatographic Systems: Evaluation of the Factors That Contribute to the Variance of Biological−Chromatographic Correlations

Hidalgo-Rodríguez, M., Fuguet, E., Ràfols, C. and Rosés, M. (2010). Estimation of Biological Properties by Means of Chromatographic Systems: Evaluation of the Factors That Contribute to the Variance of Biological−Chromatographic Correlations. Analytical Chemistry, 82(24), pp.10236-10245.
​Other important publications

Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution

Valkó, K. (2004). Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution. Journal of Chromatography A, 1037(1-2), pp.299-310.

Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC:  A High-Throughput Alternative to log P/log D

Valkó, K., Bevan, C. and Reynolds, D. (1997). Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC:  A High-Throughput Alternative to log P/log D. Analytical Chemistry, 69(11), pp.2022-2029.

Rapid‐gradient HPLC method for measuring drug interactions with immobilized artificial membrane: Comparison with other lipophilicity measures

Valko, K., Du, C., Bevan, C., Reynolds, D. and Abraham, M. (2000). Rapid‐gradient HPLC method for measuring drug interactions with immobilized artificial membrane: Comparison with other lipophilicity measures. Journal of Pharmaceutical Sciences, 89(8), pp.1085-1096.

Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity

Valko, K., Nunhuck, S., Bevan, C., Abraham, M. and Reynolds, D. (2003). Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity. Journal of Pharmaceutical Sciences, 92(11), pp.2236-2248.

Rapid Method for the Estimation of Octanol / Water Partition Coefficient (Log Poct) from Gradient RP-HPLC Retention and a Hydrogen Bond Acidity Term (∑α2H)

Valko, K., Du, C., Bevan, C., Reynolds, D. and Abraham, M. (2001). Rapid Method for the Estimation of Octanol / Water Partition Coefficient (Log Poct) from Gradient RP-HPLC Retention and a Hydrogen Bond Acidity Term (Sigma alpha2H). Current Medicinal Chemistry, 8(9), pp.1137-1146.

Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning

Hollósy, F., Valkó, K., Hersey, A., Nunhuck, S., Kéri, G. and Bevan, C. (2006). Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning. Journal of Medicinal Chemistry, 49(24), pp.6958-6971.

In Vitro Measurement of Drug Efficiency Index to Aid Early Lead Optimization

Valko, K., Chiarparin, E., Nunhuck, S. and Montanari, D. (2012). In Vitro Measurement of Drug Efficiency Index to Aid Early Lead Optimization. Journal of Pharmaceutical Sciences, 101(11), pp.4155-4169.

Predictive approaches to increase absorption of compounds during lead optimisation

Valko, K., Butler, J. and Eddershaw, P. (2013). Predictive approaches to increase absorption of compounds during lead optimisation. Expert Opinion on Drug Discovery, 8(10), pp.1225-1238.